New and emerging therapies in psoriasis.
نویسندگان
چکیده
This article discusses the scientific rationale for the use of cytokine inhibitors, including ustekinumab, an inhibitor of the interleukin (IL)-12 and IL-23 pathways in psoriasis. Also addressed are the efficacy and safety data for this agent, as well as for several emerging therapies that target other cytokine pathways in psoriasis: the IL-17 inhibitors secukinumab, ixekizumab, and brodalumab, the IL-23 blocker tildrakizumab, and the small-molecule kinase inhibitors apremilast (a phosphodiesterase-4 blocker) and tofacitinib (a Janus kinase inhibitor).
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عنوان ژورنال:
- Seminars in cutaneous medicine and surgery
دوره 33 2 Suppl 2 شماره
صفحات -
تاریخ انتشار 2014